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Description

Mice in the vehicle cohort received three subcutaneous (SC) saline (1 ml/kg) injections/day (~0930, 1330, 1730 h) and mice in the treatment cohort received three SC injections of the NNMT inhibitor 5-amino-1MQ at a dose of 20 mg/kg/injection for a total dose of ~34 mg/kg/day of the parent compound (calculated according to free weight) for 11 days

NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives immune evasion in urothelial carcinoma by elevating PD-L1 N-glycosylation

| 2024 Edition Researchers interested in acquiring 5-amino-1MQ for experimental or educational purposes may legally procure it online

Figure 5B)

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P