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By focusing on mechanistic in vitro and in vivo studies, this review consolidates current preclinical findings, clarifies their experimental context, and highlights critical limitations, most notably the scarcity of mechanistic human data

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Data Animal Data In pregnant rats given daily subcutaneous doses of zoledronic acid of 0.1, 0.2, or 0.4 mg/kg during organogenesis, fetal skeletal, visceral, and external malformations, increases in pre-and post-implantation loss, and decreases in viable fetuses and fetal weight were observed at 0.2 and 0.4 mg/kg/day (equivalent to 2 and 4 times the human 5 mg intravenous dose, based on AUC)

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BPC-157 is supplied as a lyophilised white powder with a molecular weight of 1419.5 Da and molecular formula C62H98N16O22