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Using integrated genomic analyses, we characterized extensive NRF2-dependent enhancer RNA (eRNA) synthesis and NRF2-mediated H3K27ac deposition at proximal and distal enhancer regions regulating these genes

This in turn activates ZBP1-dependent necroptosis and effectively reverses the insensitivity to ICIs in mouse melanoma models (Zhang T

Colley DG, Andros TS, Campbell CH Jr

One explanation is the accumulation in the brain of a modified form of the Ab protein (consisting of 42 amino acid residues), which fails to properly bind metals, promotes oxidative processes