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According to the article Red Alert on Skincancer.org: Researchers also found people with one copy of the crucial MC1R gene who may be fair-skinned but not have red hair also have a higher risk for skin cancers

isoform '1' encodes p16(INK4a), while isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor suppressor protein p53

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Some nevus cells remain at the DEJ while others eventually migrate down into the dermis, accounting for some of the normal physiologic changes that can occur throughout the life span

[DOI] [PubMed] [Google Scholar] 11.Seneschal J., Boniface K., DArino A., Picardo M