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Because unbound drug concentration is determined by dosing rate and clearancewhich is not altered, in the case of these low-extraction-ratio drugs, by protein bindingincreases in dosing rate will cause corresponding changes in the pharmacodynamically important unbound concentration

[36] [37] In likely relation to this fact, endogenous oxytocin concentrations in the brain have been found to be as much as 1000-fold higher than peripheral levels

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It has been shown to significantly reduce visceral adipose tissue (VAT) in multiple randomized trials (NEJM/phase III evidence

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This mechanism gives researchers insights into how cellular energy balance relates to methylation processes and NAD+ availability