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Moreover, active efflux transporters, such as breast cancer resistance protein (BCRP), P-glycoprotein (P-gp), and multidrug resistance-associated proteins (MRPs), expel many therapeutic agents from the endothelial cells back into the bloodstream, significantly reducing their CNS infiltration 69,70

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10.1111/jcmm.70175 J Cell Mol Med

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doi:10.1007/s10815-024-03096-8 874. El-Dessouky SH, Issa MY, Aboulghar MM, Gaafar HM, Elarab AE, Ateya MI, Omar HH, Beetz C, Zaki MS

At baseline, cDC1s are more heavily reliant on oxidative phosphorylation compared to cDC2s or pDCs, likely due to their larger mitochondrial mass and membrane potential (7274)