glutathione s transferase function S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells The role of glutathione S-transferases

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According to Song et al., Adriamycin-resistant cells exhibited a marked overexpression of P-gp and NF-kB signaling pathway, and NF-kB inhibitor BAY1-7082 could overcome drug resistance through blocking the pathway and downregulating P-gp expression (124)

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