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Together, this evidence suggests that while mutations or inadequacy of DNA repair mechanisms may play a role in promoting cancer neogenesis and progression, these deficiencies may increase sensitivity of cancer to therapy

USA 94 , 43184323 (1997)

Food and Drug Administration (2024) 2

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Thus, the combination of estrogen and insulin signaling mediate the growth and proliferation of luminal breast cancer by enhancing the glycolytic pathway