For inflammatory bowel disease, BPC-157 mitigates intestinal inflammation, reduces lesion size, and promotes epithelial lining regeneration
In the situation of I/R injury, NSAIDs have been shown to attenuate the production of pro-inflammatory cytokines (e.g., TNF- , IL-6) and reduce microglial activation, which are key drivers of neuroinflammation (Ajmone-Cat et al., 2010)
(1997) ArticleTitlePentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats J Physiol (Paris) 91 11322 Occurrence Handle10.1016/S0928-4257(97)89474-0 Occurrence Handle1:CAS:528:DyaK2sXotVKhs7c%3D M Veljaca CA Lesch R Pllana B Sanchez K Chan A Guglietta (1995) ArticleTitleBPC-15 reduces trinitrovenzene sulfonic acid-induced colonic damage in rats J Pharmacol Exp Ther 272 41722 Occurrence Handle7815358 Occurrence Handle1:CAS:528:DyaK2MXjtFSqtb0%3D I Zoricic P Sikiric S Seiwerth (1997) Pentadecapeptide BPC 157 beneficially influences the healing of colon-colon anastomoses in rats G Mozsik L Nagy A Par KD Rainsford (Eds) Cell injury and protection in the gastrointestinal trace
Funding This work was supported by the National Nature Science Foundation of China (81902162, U21A20347), the Swedish Research Council (2018-02267), Swedish governmental grants to scientists working in healthcare (ALFGBG-965197), the Henan Provincial Science and Technology Department (222102310161, 182102310688, 202102310221), and the Henan Province Medical Research Project (LHGJ20190349)
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Genes related to ferroptosis were found to be differentially expressed in microglia after SCI, with the most significant changes in Stmn1 and Fgfbr1
