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Studies focused exclusively on microbial persistence or antibiotic tolerance, or those unrelated to cancer, were excluded ( 2.3 Study selection Three reviewers independently screened all the titles and abstracts (n = 770)

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Intra-observer and inter-observer variations also affect results

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According to our experience (68), GC linked to Hp infection was accompanied by a 2-3 fold higher CagA seropositivity in GC than in age-matched non-GC Hp positive controls, indicating that out of several tested parameters (CagA, plasma gastrin, IL-8, gastric acid secretion), the CagA seropoositivity appears to be one of the best discriminative parameters between GC and controls as determined by multivariable analysis with logical regression and that this parameter might be a useful marker of gastric carcinogenesis (68) ( Fig