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There was a trend for the patients who experienced these events to have a lower baseline albumin concentration, lower valproate clearance, and a higher BUN

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L-carnitine suppressed NF-B expression and downregulated key inflammatory mediators, including NLRP3 inflammasome, Toll-like receptor 4 (TLR4), and c-Jun N-terminal kinase (JNK) ( Synergistic upregulation of energy metabolism and insulin signaling genes: Salic et al

Green et al., 2012)

This is not surprising as only 23% of children with ASD and MD have a known mtDNA abnormality

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