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Beyond generating ROS to induce ICD, more sophisticated structural designs can integrate multiple therapeutic modalities into a single COF platform, creating stronger synergistic effects to more effectively ignite the immune response

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To address its inherent instability, advanced delivery systems including enteric-coated, sustained-release, and micro-encapsulated formulations are developed to enhance its shelf life, gastric tolerance, and overall bioavailability

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Reduced binding to IGF-binding proteins allows prolonged receptor engagement, ensuring sustained signaling in in vitro and preclinical research models

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