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Contraindicated in patients with a history of maple syrup urine disease

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Additional studies to investigate the mechanism for this pathology have not been performed, and the potential significance of this effect in humans has not been established

Nicotinamide Adenine Dinucleotide (NAD+) is a critical coenzyme investigated in cellular biology for its fundamental role in electron transport and redox reactions

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Written informed consent for participation in this study was provided by the participants' legal guardians/next of kin