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4.3 Multifaceted roles of GPXs in plant biological processes The direct association of GPX2, GPX3, GPX4, GPX5, GPX7, and GPX8 with glutathione metabolic processes ( Figure 5 ) suggests that the proteins can use glutathione as an electron donor in reducing H 2 O 2 or organic and lipid hydroperoxides to maintain plant cell redox homeostasis ( Supplementary Table S2 ) (Yang et al., 2005)

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Therefore, ROS concentration needs stringent control

Notably, the enantiomer D-carnitine may exert hepatotoxic effects (89), underscoring the critical importance of compound-specific safety evaluation and reinforcing that only the biologically active L-isomer should be considered for therapeutic use in MASLD