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Additionally, oxidative stress can induce necroptosis through ROS accumulation, further damaging oocyte quality

We observed the same in our cohort of 70 patients: compared to patient matched healthy tissue, tumors had significantly higher levels of GSSG which they appeared to redox-balance by enhancing GSH production, reflected by a an accumulation of GSH as well as its precursors (Fig

Rotman M, Welling MM, Bunschoten A, de Backer ME, Rip J, Nabuurs RJA, Gaillard PJ, van Buchem MA, van der Maarel SM, van der Weerd L (2015) Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimers disease

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In mouse hearts that underwent myocardial infarction, with a uniform distribution of B-017 throughout the cardiac tissue, the typical hallmarks of both apoptosis and necrosis have been markedly reduced, while the cardiac metabolism has undergone a notable alteration upon B-017 administration

Beck DE, Sweeney WB, Mccarter MD