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IGF2BP3s role was validated through knockdown/overexpression, patient-derived organoids (PDOs), and xenograft models

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Peripheral neuropathy may take 36 months to improve, and some patients experience incomplete recovery, particularly if treatment was delayed

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These protein aggregates exert toxic effects on neurons, leading to cellular dysfunction and death [193]

Their findings indicated a notable suppression of matrix metalloproteinase, TGF- expression and increase in antioxidant markers in limonene treated rats, suggesting the protective role of d-limonene in the management of UC [110]