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According to the mitochondrial free radical theory of aging, the production of mitochondrial derived ROS and related mitochondrial dysfunction are the key driving forces in the process of aging (Tarantini et al., 2018)

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Int Immunopharmacol 114:109571 Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Results: Among randomized subjects, 25 in the EFI group and 26 in the SEMA group were HISP

It plays a key role as a direct precursor to NAD+

Nevertheless, until long-term human data accumulates, the precautionary approach remains appropriate