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To generate the transgenic lines, we used the skeletal muscle-specific myosin light chain 2 ( mlc2 ) promoter to express the wild-type (WT) human LMNA as well as the five different LMNA mutations, while the heart-specific myosin light chain 7 ( myl7 ) promoter was used to drive the expression of the EGFP transgene as a reporter

[4] [5] [6] Following oral administration, methamphetamine is well-absorbed into the bloodstream, with peak plasma methamphetamine concentrations achieved in approximately 3.136.3 hours post ingestion

For screened, appropriate candidates administered under medical oversight, IV therapy is generally well tolerated, with temporary effects like mild bruising at the site or a cool sensation during infusion