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The following chapters will therefore focus on clinical evidence and practical applications rather than reiterating mechanistic details

Show details ABSTRACT Obesity is pandemic and a multidisciplinary approach is critical for its management

10.1016/S0891-5849(01)00686-4

[166b] Spinal cord motor neurons [210] and SNc dopamine neurons are prone to mild redox dyshomeostasis, mitochondrial dysfunction and protein misfolding during healthy aging, [166b] which become progressively exacerbated by additional pathogenic factors such as genetic mutations, biometal dysregulation (Cu, Fe) or exposure to toxins

Thus, 7 hydroxycholesterol can be acted upon by a C27 hydroxylase and several other peroxisomal enzymes, which shorten the alkyl side chain and add a carboxylic acid function to yield the bile acid chenodeoxycholic acid