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Mechanistically, DUSP2 directly dephosphorylates STAT3 at Tyr705 and Ser727 residues, leading to inactivation of STAT3

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In these species, reactive oxygen species (ROS)comprising radicals (e.g., superoxide (O 2 )) and non-radical derivatives (e.g., hydrogen peroxide (H 2 O 2 ))can engage in complex chemical interactions with other reactive species before interacting with larger biomolecules, such as nucleic acids, proteins, lipids, or carbohydrates [2,10,11] (Figure 1)

Metabolomics changes in brain-gut axis after unpredictable chronic mild stress