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In glycolysis, ROS oxidize GAPDH and PKM2, altering their activity, thereby inhibiting glucose uptake, while simultaneously enhancing glucose uptake and metabolism through HIF1 stabilization

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Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy

With the high-quality separation, the metabolites were readily assigned based on predicted molecular formulas without complications due to overlapping of the m/z series from co-eluting metabolites

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Targeting antioxidant pathways may therefore offer a novel avenue for CRC treatment in the future