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require documentation of indication, dosing, and clinical response Biologics (IL-12/23 inhibitor): Ustekinumab (Stelara, J3357) FDA-approved for moderate-to-severe CD

Muscle weakness and loss of muscle tone in the feet and lower legs

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Less Common but Possible Headache or dizziness: Likely tied to shifts in appetite and energy regulation

Research also suggests it helps with the integration of bone grafts, which could be beneficial for certain surgical procedures

Acta 1843 , 20792088 (2014)