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The formation of these adducts can subsequently result in protein crosslinking, structural perturbation, protein aggregation and inactivation of protein function 52,53,54,55,56

TABLE 1 Evidence map of curcumins effects across key oral disease areas ( in vitro in vivo clinical)

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Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

Untreated diabetes caused an impairment of 20-40% in all endpoints

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