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Additionally, the activity of tau kinase, which causes tau hyperphosphorylation, and the amount of pTau protein were increased

In summary, the discovery of ferroptosis expands our understanding of CD in CCVDs, and targeting ferroptosis will provide a new strategy and broaden thoughts for the prevention and treatment of CCVDs

The other main roles of arhalofenate are to activate AMPK, inhibit NF-B and NLRP3 inflammasomes to promote the polarisation of anti-inflammatory macrophages, as well as significantly reduce UA-induced inflammation (Salminen et al., 2011

Moreover, ovarian aging is associated with an increased risk for diabetes, heart disease, cancer, and other age-related conditions

Malik et al., 2022)

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