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Clark, Taane G

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11

Consistent with the established role of activated microglia in synaptic pruning, our data demonstrated a significant increase in SYNAPTOPHYSIN1 + puncta within microglia and their lysosomes, indicating enhanced engulfment of presynaptic terminals and suggesting that microglial activity under these conditions may contribute specifically to presynaptic terminal loss [93]