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JAMA Neurol (2023) 80(4):40414

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In addition, recently it was shown that two monocot model species Oryza sativa and Setaria viridis are capable of oxidizing cysteine to sulfate, a reaction that is not present in Arabidopsis [20]

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It appears that the cells that proliferate initially are Schwann cells, and it is these cells that have NF1 mutations in both alleles.42 The presence of at least 2 cutaneous neurofibromas or at least 1 plexiform neurofibroma is a diagnostic criterion for NF1