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While N6F11 has shown some cell-specific properties, it requires higher concentrations to achieve effectiveness compared to well-known non-selective ferroptosis activators [36]

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To accommodate the tumors growth, there is an upregulation in the expression of angiogenic factors like vascular endothelial growth factor (VEGF), leading to the abnormal proliferation and expansion of tumor vasculature, a hallmark of high-grade gliomas [145]