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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan

in the human study, this was demonstrated by the differences in blood lactate concentrations following exercise between the placebo and glutathione trials

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It also increases the vesicular glutamate transporter 1 protein (VGLUT1) and glutamate decarboxylase (GAD) levels in the hippocampus (45)