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Exposure of astrocytes to extracellular L-lactate and selective HCA1 agonists, 3Cl-5OH-BA 626 or Compound 2 627 , triggers responses similar to those mediated by -adrenoceptors 628,629,630 , namely an increase in cAMP, cAMP-dependent PKA activity and L-lactate production

But most patients eventually develop drug resistance

Complementing these preliminary positive signals was the observation that delta-9-THC and delta-9-THC/CBD treatments significantly reduced urinary urge incontinence episodes in MS patients [79]