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Transcriptional activity of forkhead box protein O3 (FOXO3) was reduced ( p = 0.0207) in hearts subjected to IRI, compared to aerobic control

doi: 10.2174/0125899775373406250411104442, PMID: [DOI] [PubMed] [Google Scholar] Surez Castro E., Santos-Garca D., de Deus Fonticoba T., Expsito Ruz I., Tuas Gesto C., Macas Arrib M

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Results The review underscores key features of listeriosis, including its historical development, epidemiological trends, notable outbreaks and their public health implications, Listeria pathogenesis, and virulence attributes, recent advancements in detection and prevention, and the economic and social consequences of the disease

Key virulence factors include internalin-mediated host cell adhesion and invasion, flagella-driven motility, the positive regulatory factor A (PrfA)-regulated transcriptional control of major virulence genes, the listeriolysin O-induced disruption of phagosomal membranes, the phospholipase-mediated evasion of host defense mechanisms, actin polymerization-dependent intracellular and intercellular spread, sigma factor-driven stress responses, biofilm formation and the development of resistance to antimicrobial agents