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2014 [96] showed that adhesion molecules (PSGL-1 and CD 11a) and C-C chemokine receptor type 9 (CCR9) on Th cells and cytotoxic T cells significantly increased in both blood and mesenteric lymph nodes after induced colitis

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Furthermore, sourcing introduces uncertainty in sterility and formulation integrity, which may represent a more immediate and clinically relevant risk than theoretical biologic effects, particularly given the potential for nonsterile preparation, contamination, or inconsistent formulation in nonregulated injectable products

NRF-2022R1A2C1011742 & NRF-2022R1A6A3A01087055)

Cancer : In rare cases, this condition can be a paraneoplastic syndrome, meaning it is associated with an internal malignancy, such as stomach, liver, or colon cancer

Current CNS-directed treatments rely on neurotoxic intrathecal chemotherapy, underscoring the urgent need for novel targeted strategies