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Additionally, a transient MCAO CX3cr1-Cre mouse model with conditional knock-in overexpression of the chloride transmembrane transporter, Swell1, resulted in anti-inflammatory microglial activation and reduced brain injury (Chen et al., 2023)

Down-regulation of inducible nitric oxide synthase (iNOS) in AD-model mice, and subsequent decrease in NO, has been associated with rescue of cognitive function, reduction in Ab and NFT load, decreased glial activation, and attenuated neuronal loss [9-11]

(-)-Epigallocatechin-3-gallate, the most abundant and active compound in green tea, possesses a potent antioxidant capacity and exhibits versatile pharmacological activities (Sun et al., 2016)

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