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Magnetic resonance imaging showed that iron deposition is correlated with cognitive impairment, and this deposition is mainly observed in the hippocampus, cortex, and basal ganglia, where brain cells experience oxidative stress, lipid peroxidation, and increased cystine/Glu transporter expression, iron metabolism, and balance (Masaldan et al., 2019)

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In the SYSUCC-002 study, endocrine therapy combined with trastuzumab demonstrates efficacy not inferior to that of chemotherapy combined with trastuzumab, while also reducing the toxic side effects associated with chemotherapy and improving patient compliance

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