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coli provokes the development of oxidative stress, which is accompanied by cascade irreversible redox modifications of proteins with the participation of cysteine and glutathione

This sets the stage for neuroinflammation, which amplifies oxidative stress and excitotoxicity, as discussed in subsequent sections

Key molecular pathways include the inhibition of TNF- and IL-1, along with the modulation of NF-B, along with genes associated with cartilage homeostasis, such as those encoding for type II collagen and aggrecan, contributing to their protective effects against OA progression

Its a naturally occurring peptide that plays a crucial role in cell migration, differentiation, and inflammation modulation

Chen R, Zeng Z, Zhang YY, Cao C, Liu HM, Li W

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