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In a phase 3, double-blind placebo-controlled multicenter trial (n=94), participants with a history of recurrent AHP attacks (2 in the 6 months before enrollment) givosiran (2.5 mg / kg monthly) treatment resulted in a 73% reduction in mean annualized attack rate compared with placebo treatment

After being synthesized from glucose in astrocytes, L-serine is shuttled to neurons to fuel the synthesis of D-serine, and the serine shuttle mechanism adds to other possible forms of metabolic interchange between astrocytes and neurons (Wolosker and Radzishevsky, 2013)

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Gyurkovics M, Lohinai Z, Gyorfi A, et al

"CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting"