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Mitochondria play an important role in the life and death of the living cell

Human and mouse brains were either perfused or rinsed with PBS (pH 7.4)

Studies have shown that pretreatment of cells with an inhibitor of glutathione biosynthesis (buthionine sulfoximine) reduces NPSH levels in the cell, resulting in enhancement of both the cytotoxicity and mutagenicity of arsenic

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This response aligns with previous findings in breast and melanoma cancer models, in which adipocyte-derived EVs, leptin, and fatty acids promote mitochondrial reprogramming and fatty acid oxidation in tumor cells [22,87,108,116]