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GSH actively attends to oxidative free radicals and, in doing so, becomes oxidized and converts to the inactive GSSG

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Studies by Pickart and colleagues published in 2012-2018 showed that GHK-Cu treatment of cultured human fibroblasts altered expression of several thousand genes, with patterns indicating increased expression of genes involved in tissue repair, antioxidant responses, protein synthesis, and cellular rejuvenation

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Upon activation, the receptor moves into the nucleus and forms a heterodimer with the aryl hydrocarbon receptor nuclear translocator (ARNT)