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It's not a suggestion, it's a chemical necessity

The optimal dose depends on individual tolerance and the specific weight-loss goal being pursued

Ann Trans Med (2020) 8(12):748

Beyond conventional liver function markers such as aspartate transaminase (AST) and alanine aminotransferase (ALT), several other liver-derived indices exhibit characteristic changes concurrent with clinical and pathological progression of AD [31]

Pan G, Chen Z, Zheng H, Zhang Y, Xu H, Bu G, Zheng H, Li Y (2018) Compensatory mechanisms modulate the neuronal excitability in a kainic acid-induced epilepsy mouse model