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The researchers noted that: "This is the first time that an effective reversal of induced- and naturally-occurring disease phenotype has been achieved for MMVD, albeit under cell culture conditions, and has implications for understanding pathogenesis and discovery of novel therapeutic options applicable to MMVD." In November 2019, researchers at Tufts' Cummings veterinary school announced an intention to conduct a clinical study in which MVD-affected cavaliers in Stage B2 (murmur and enlargement but not CHF) will be injected with an AAV medium which will contain " transforming growth factor beta receptor 2 (sTGFBR2) ", a repressor of TGF-B1, in that it inhibits the action of TGF-B1, most likely by adsorbing TGFB1 or by acting as a dominant negative receptor

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Activation of microglia and increased expression of glial genes observed in ASD patients further support the role of neuroinflammation in ASD pathon important role in the immune-inflammatory mechanisms of ASD

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