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The treatment of PEH is challenging: On the one hand, watchful waiting carries the risk of developing acute life-threatening complications requiring an emergency operation

[188] In January 2011, an investigation published in the journal BMJ described the Wakefield study as the result of deliberate fraud and manipulation of data

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This extracellular signal binds to P2 purinergic receptors on bacterial membranes, modulating biofilm formation and virulence gene expression in pathogens like E.coli 73,74

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Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function