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By identifying molecular markers associated with drug resistance, researchers can design more targeted treatment strategies to overcome existing limitations in treatment

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The pK a of Tyr9 is 8.1 in the free GST A1-1, but the value increases to 9.2 when glutathione is bound ( a appears dependent on the ionized thiolate, since S-methylglutathione is without effect on the ionization of Tyr9