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Research has demonstrated a significant difference in the percentage of m6A-modified mRNAs between AD tissue samples and healthy aortas, indicating a distinct molecular landscape in the pathology of the disease

204,207 These results raise the possibility that RNAP II and mtRNAPs might function as both sensors and executors, which sense NAD + /NADH ratios and induce the NAD + capping to regulate the gene expression, leading to the crosstalk between cellular NAD + metabolism and transcriptional activity