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In contrast, MYC was more activated in HCC tumors showing no benefit of the treatment, suggesting that MYC may trigger resistance of HCC cells to sorafenib

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The efficacy of the checkpoint inhibitor immunotherapy is augmented in the presence of Bifidobacterium and Bacillus fragilis through the shaping of the host immune system (145, 146)

doi: 10.3389/fonc.2023.1143798 Received 13 January 2023 Accepted 24 February 2023 Published 07 March 2023 Volume 13 - 2023 Edited by Parmanand Malvi, University of Alabama at Birmingham, United States Reviewed by Sanjay Pandey, Albert Einstein College of Medicine, United States