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Furthermore, this phenomenon is exclusive for VPA as treatment with other anticonvulsants, such as carbamazepine or lamotrigine did not trigger alteration in the expression of SCN3A

In PubMed, a representative Boolean search structure was constructed based on controlled vocabulary and free-text terms and modified to suit the other databases

The bloodbrain barrier (BBB) with its tight junctions, membrane transporters, receptors and metabolizing enzymes is a main player in drug delivery to the brain, restricting the entrance of the drugs and other xenobiotics