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Plos One 18 (11), e0294280

5-Amino-1MQ is a small molecule that inhibits the enzyme nicotinamide N-methyltransferase (NNMT)

References Perricone, V., et al

These results suggested that TRIP12OTUD5 antagonism may regulate the NF-B inflammatory signaling pathway

Although the expression patterns of these genes vary, they predominantly encode pro-inflammatory cytokines, type I interferons (IFN-I) (e.g., IFN- and IFN-), chemokines, and proteins that modulate PRR-mediated signaling, which collectively shape the inflammatory process (42) ( Figure 3 )

The safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: an update