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Ferritin upregulation inhibits estradiol synthesis via the NF-B/iNOS pathway and downregulates the Nrf2/GPX4 pathway, exacerbating ovarian damage (Sze et al., 2022)

However, the lab-engineered, synthetic form is typically used in skin care formulas because of its greater stability and effectiveness

doi: 10.4103/2230-8210.189231

Thus, EOs are increasingly used as alternatives to traditional drugs for treating inflammation (Shen et al., 2017)

SPX proteins, as phosphorus receptors, can avoid toxicity caused by phosphorus over-accumulation by interacting with PHR1 ( Arabidopsis ) or PHR2 ( Oryza sativa ), and inhibiting their transcriptional activities under normal conditions, while SPX proteins do not affect PHR transcriptional activities when plants are in low phosphorus environments (Wang et al., 2014)

Moreover, Mg availability influences hormonal crosstalk at the transcriptional level, particularly within pathways regulated by ABA and ethylene, which control stomatal closure, senescence, and stress acclimation