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CTAR1 directly recruits the TNF receptor-associated factor (TRAF) family members TRAF1, 2, and 3 via its TRAF-binding consensus motif P 204 xQxT to induce noncanonical and atypical NF-B signalling, phosphoinositide 3-kinase (PI3K), and the mitogen-activated protein kinase (MAPK) pathways ERK and p38 (Fig