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Hydrogen peroxide produced by superoxide dismutase SOD-2 activates sperm in Caenorhabditis elegans

SCD patients have aberrant metabolic regulation of fumarate, glutamate, glycine, malate, and other metabolites involved in glycolysis, nucleotide catabolism, and glutathione metabolism 3,4,5,6

For instance, if the activity of superoxide scavenging by SOD2 exceeds the capacity to remove the H2O2 generated, this oxidant can cause oxidative damage or be converted to other ROS

doi: 10.1007/s12640-017-9835-5 142 TaeneAKhalili-TanhaGEsmaeiliAMobasheriLKooshkakiOJafariSet al

doi: 10.1128/mBio.01139-20 86 SeoHChoY-CJuALeeSParkBCParkSGet al

doi: 10.1016/j.ejphar.2018.06.023 60