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Osterlund E, Maddalena G, Pellatt AJ, Vetere G, Eluri M, Parseghian C, Aziz KE, Alfaro K, Kell RJ, Konishi T, Overman MJ, Morelli MP, Willis J, Shen J, Raghav K, Newhook T, Shen X, Morris V, Dasari NA, Kopetz S

The motheaten phenotype is due to a splicing mutation in SHP1 causing an absence of detectable protein and mice that have severe disorders of hematopoietic cells resulting in death within 3 weeks after birth (148)

This chronic inflammation subsequently promotes the development of reactive stroma, a fibrotic ECM structure enriched with activated CAFs and an overproduction of ECM proteins

You cannot force cell turnover without disrupting the existing barrier

Sixty-six pups from six dams were separated from the dams and divided into Groups 2 and 3, as described below