Berberine is a natural compound with a 3000 year history of use in Ayurvedic and Chinese medicine
It also had the highest total flavonoid content (TFC) (147)
Eisenberg, M, Deboever, N, Hofstetter, WL, Mehran, RJ, Rice, DC, Rajaram, R, Swisher, SG, Vaporciyan, AA, Walsh, GL, Antonoff, MB

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Yang et al., 2009), rotenone (Kitamura et al., 2002
Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA), 212 low-density lipoprotein receptor-related protein 1 (LRP1), 213 lipoprotein lipase (LPL), 214 SREBF1/2, 215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-, and TGF-1) 216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders